Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, Cell therapy may be a novel alternative.

Chronic leg ulcers (CLU) are a common and complicated disease to treat and result in high morbidity and significantly reduced quality of life.

The role of cell therapies in the treatment of chronic, non-healing wounds is continuously being refined within the scope of tissue engineering. Cells promote restoration of impaired signaling pathways for growth factors, delivery of important cytokines and chemokines, induction of vascularization and innervations, and more precise control of the inflammatory processes underlying chronic wounds.