The human body and its micro biome,residing on the surface and within the body, constitute a highly delicate system. Among them gut micro biota, promising phenomena in scientific community in recent years, is a complex microbial community that has been shown to play a major role in health and disease. The gut micro biota consists of microorganisms that reside in the host gastrointestinal tract.The gut micro biome participates in the absorption of the host’s nutrients and metabolism, maintains the microcirculation, and modulates the immune response. These microorganisms provide protection against pathogen colonization and invasion through appropriate responses, leading to inflammation or tolerance. Humans have nearly 100 trillion gut bacteria that are vital for good health.
Millions of years of coevolution have shaped the symbiotic relationship between humans and microorganisms, in which the gut bacteria play a crucial role in the metabolism of human nutrients, while the human gut provides a nutrient rich environment for the bacteria. Therefore, an imbalance in the gut micro ecology leads to the occurrence or aggravation of disease. Dysfunction of the intestinal epithelium, dysfunction of the immune system and translocation of enteropathogenic bacteria are considered to be the key factors leading to infectious complications and multiple organ dysfunction syndromes.
The gut micro biota and host’s immune system inter-depend on each other by shaping the development, composition and functions of one another. Invariably, cell-therapy does not only aim at restoring the desired host immune response but also correct the altered gut micro biota.
Microbiome have also implicated in tumor control in patients undergoing anti- angiogenesis therapy and immunotherapy. In cases with unsatisfactory responses to chemotherapy, radiotherapy, and targeted therapy, appropriate adjustment of microbe’s abundance is considered to enhance the treatment response.
The Gut Micro biome is getting attention these days for therapeutic approach as crucial part of human body. An imbalance of healthy and unhealthy microbes (Dysbiosis) linking to a plethora of diseases and conditions, from diabetes to autism and depression to obesity.
These microbes play many vital roles in our body. Like many bacteria in our body helps in digestion of food, regulate the immune system, protect against other harmful bacteria which may cause diseases, they even produce vitamins like B12, thiamine and riboflavin and also vitamin K is required for coagulation of blood.
The micro biome is very essential for development of immunity in humans. Many autoimmune diseases like diabetes, rheumatoid arthritis, multiple sclerosis and fibromyalgia are associated with the dysfunction in certain micro biome. Harmful microbes accumulate over the time, changing gene activity and metabolic processes and resulting in an abnormal immune response against the diseases. It appears that many autoimmune conditions passed in families not by DNA inheritance but by inheriting the family’s micro biome.
Determining the functional composition of a gut micro biome across different populations is essential for understanding its role in maintaining human health. India is the seventh largest country in the world and harbors the second largest population spread across multiple geographical locations with enormous diversity in ethnicity, lifestyle, and dietary habits. By studying the micro biome data in these populations we can analyze the role of gut micro biome in the individual’s health.
Expert Advice on the human Gut Microbiome • we suggest a diet rich in fruits, vegetables, whole grains, healthy fats and lean proteins. • We recommend drinking water instead of sugary drinks. •Staying active and maintaining a healthy weight is also significant. • Since probiotics feed on non – digestible carbohydrates, eating prebiotic fibers like bananas and asparagus is advised as beneficial bacteria reproduce in the gut as a result of this process. • Eat fewer sugar and sweeteners, since too much sugar or artificial sweeteners can lead to gut dysbiosis ormicrobial imbalance in the gut. • Many types of safety, like gut wellbeing, benefit from stress management. Antibiotics are often used to treat bacterial infections; however, overuse is a serious public health issue that can lead to antibiotic resistance.
We at VIECELL, provide micro biome analysis analysis through metagenomic sequencing generating personalized microbiome data of gut and trying to know the exact composition of patients gut micro biome, not only knowing but after getting proper analysis of micro biome data we will try to modify that micro biome composition in patients by providing diet plan along with pre, pro, syn and post biotic supplements. Once that micro biome is maintained to a healthy state, the cell therapy will have more potential to heal the degenerative conditions. This is scientifically interlinked cell therapy and healthy gut micro biome, once your gut micro biome is normal your body will not have harmful microbes and simultaneously cell therapy will start its regenerative and repairing work for the degenerative diseases. this combine approach is very novel which helps patients get symptomatic relief while treating the disease from root cause.