The retinal pigment epithelium (RPE) is a multifunctional monolayer located at the back of the eye required for the survival and function of the light-sensing photoreceptors. In Age-related Macular Degeneration (AMD), the loss of RPE cells leads to photoreceptor death and permanent blindness.
Current research indicates that RPE dysfunction is a major driver of AMD development. Once the photoreceptors are lost, it is difficult for patients to perform their normal daily activities.
Cell therapy provides great hope for curing degenerative eye diseases like dry AMD. Healthy transplanted cells can release factors that rejuvenate dysfunctional RPE and photoreceptors.